Dr. Reza Ghiladi | North Carolina State University
Event Date:
March 9, 2015 – 4:00 PM to March 10, 2015 – 4:59 PM
Location:
Burson 115
Event Date:
March 9, 2015 – 4:00 PM to March 10, 2015 – 4:59 PM
Location:
Burson 115
|
Department of Chemistry
|
Dr. Reza Ghiladi
North Carolina State University
“The Dehaloperoxidase Paradox: How Nature Juggles Oxygen Transport, Peroxidase, and Peroxygenase Activities at a Single Heme Active Site”
Abstract:
The enzyme dehaloperoxidase (DHP) from the terebellid polychaete Amphitrite ornata is a dual-function hemoprotein which, in addition to being the coelomic hemoglobin of this marine worm, possesses broad substrate specificity for the oxidative dehalogenation of environmental haloaromatic toxins such as trihalophenols. As such, DHP is the first globin identified to possess a biologically relevant peroxidase activity, and thus provides a unique system to explore our understanding of metalloprotein mechanism, activation, and design. In the context of the protein structure-function relationship, discussion will focus on the link between peroxidase, O2-transport, and newly identified peroxygenase activities which furthers our understanding of how dehaloperoxidase is able to perform three enzymatic functions at a single catalytic active site.
Bio:
Reza Ghiladi received a B.S. in Chemistry from Haverford College in 1995. He then pursued advanced training in synthetic inorganic chemistry with Prof. Ken Karlin at Johns Hopkins University, earning an M.A. in 1997 and a Ph.D. in 2001. Following postdoctoral work at the Mayo Clinic under Prof. Frank Rusnak as the Kendall-Mayo Fellow in Biochemistry, he continued his training as an NIH Postdoctoral Fellow at the University of California at San Francisco under Prof. Paul Ortiz de Montellano. Dr. Ghiladi joined the Department of Chemistry at North Carolina State University in 2006 as an Assistant Professor, was the recipient of a 2012 National Science Foundation CAREER Award and the 2013 LeRoy and Elva Martin Award for Teaching Excellence, and currently holds the rank of Associate Professor.
Monday, March 9, 2015 @ 4:00pm Burson 115
Refreshments served @ 3:45