Dr. Lin He | N.C. State | “Label-free, Multiplexed Bioassays on Metallic Striped Nanorods”

Event Date:
September 4, 2014 – 3:30 PM to September 5, 2014 – 4:59 PM

Location:
Burson 115

Event Date:
September 4, 2014 – 3:30 PM to September 5, 2014 – 4:59 PM

Location:
Burson 115

Ph.D Nanoscale Science
Seminar Series
Fall 2014

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Lin He
North Carolina State University

Department of Chemistry

“Label-free, Multiplexed Bioassays on Metallic Striped Nanorods”

Abstract:

Biological multiplexing is one of the fastest growing areas in life science research because of its potential for extracting the most information from the smallest amount of sample volume at low cost. Traditional multiplexed bioassay platforms often require an extra labeling step for the targets or the probes with reporter molecules, which prolongs assay time and increases assay cost.

The need to overcome such hurdles has motivated our research on the development of a label-free multiplexed assay system where polythiophene derivatives are used in conjunction of metallic striped nanorods for multiplexed DNA detection. The same multiplexed label-free assay concept has also been expanded to monitor other molecular interactions where DNA binding is involved. Our recent efforts on monitoring conformational changes of biomolecules in a label-free fashion using surface plasmon enhanced circular dichroism spectroscopy at single particle level will also be presented.

Bio:

Dr. Lin He is an Associate Professor of Chemistry at North Carolina State University (NSCU). Adjunct Professor, Joint Department of Biomedical Engineering, UNC/NCSU; Honorary Professor, Southeast University, PR China. She received her Ph.D. from The Pennsylvania State University (2000) and B. S. from Peking University (1996).

Thursday, September 4, 2014 @ 3:30 PM in Burson 115
Coffee & soft drinks served at 3:15 PM