Dr. Peixuan Guo | University of Kentucky | “Studies on viral DNA packaging motor for RNA nanotechnology, therapeutics delivery, single chemical detection, single pore DNA sequencing, and single molecule imaging”
Event Date:
April 22, 2015 – 4:00 PM to April 23, 2015 – 4:59 PM
Location:
Burson 115
Event Date:
April 22, 2015 – 4:00 PM to April 23, 2015 – 4:59 PM
Location:
Burson 115
Ph.D Nanoscale Science
Seminar Series
Spring 2015
Dr. Peixuan Guo
University of Kentucky
Nanobiotechnology Center, Markey Cancer Center & College of Pharmacy
“Studies on viral DNA packaging motor for RNA nanotechnology, therapeutics delivery, single chemical detection, single pore DNA sequencing, and single molecule imaging”
Abstract:
This talk will starts with the delivery of information for studies on bacteriophage phi29 DNA packaging motor involving chemical, biophysical, biochemical and single molecule imaging technologies, and how the study on this motor has led to the discovery of a third type of biological motor using revolution mechanism without rotation, and to the development of single pore sensing, single chemical detection, single pore DNA sequencing, and early disease diagnose, and to the emergence of the new field of RNA nanotechnology.
Bio:
Dr. Guo received his Ph.D. in Microbiology and Genetics with training in biophysics from the University of Minnesota in 1987. He was a postdoc at NIH before joining Purdue University as an assistant professor in 1990, tenured in 1993, full Professor in 1997, and was honored as a Purdue Faculty Scholar in 1998. He founded two Interdisciplinary Graduate Programs and established a NIH Nanomedicine Development Center at Purdue. He was recruited to University of Cincinnati as the Dane & Mary Louise Miller Endowed Chair of Biomedical Engineering in 2007, and was Director of the NIH Nanomedicine Development Center relocated from Purdue to University of Cincinnati. He moved to University of Kentucky as William Farish Endowed Chair in Nanobiotechnology in 2012, and currently is the UK Director of Nanobiotechnology Center and Director of NCI Cancer Nanotechnology Platform Partnership Program in RNA Nanotechnology for Cancer Therapy.
He constructed the first viral DNA packaging motor in vitro (PNAS, 1986), discovered phi29 motor pRNA (Science, 1987), assembled the first infectious dsDNA viruses using synthetic and purified components (J Virology, 1995), discovered pRNA hexamer (Mol Cell, 1998, featured in Cell), and pioneered RNA nanotechnology (Mol Cell, 1998; JNN, 2003; Nano Letter, 2004, 2005; Nature Nanotech 2010, 2011). His lab built a dual imaging system to detect single-fluorophores (EMBO J, 2007; RNA, 2007), incorporated the phi29 motor channel into a lipid membrane (Nature Nanotech, 2009) for single molecule sensing with potentials for high throughput dsDNA sequencing. Recently, his lab discovered a third class of biomotor using revolution mechanism without rotation (https://www.youtube.com/watch?v=LpUGuEQos6Y). His work has been reported hundreds of times over the radio or TV such as ABC, NBC, BBC, and featured in Newsletters or websites of NIH, NSF, MSNBC, NCI and ScienceNow etc. He was a member of two prominent national nanotech initiatives sponsored by NIST, NIH, NSF and National Council of Nanotechnology; member of the NIH NDC Steering Committee from 2006-2010; NIH/NCI intramural site-visit Review Panel at 2010 and 2014; Panelist for DOD-US Army, Navy & Air Force Joined Medical Program in 2003; member of the Examination and Review Panel (Oversea Expert) of the Chinese Academy of Sciences since 2014.
Wednesday, April 22, 2015 @ 4:00 PM in Burson 115
Coffee & soft drinks served at 3:45 PM